Both Daxxify and Botox are popular injectable treatments that aim to reduce wrinkles and fine lines. However, choosing the right one for your cosmetic goals can be challenging. In this blog, we will compare Daxxify and Botox based on their effectiveness, longevity, side effects, and cost to help you make an informed decision.
What Is Daxxify?
Daxxify is a newer injectable treatment that uses peptide technology to reduce wrinkles by relaxing the muscles underneath the skin. Daxxify (daxibotulinumtoxinA-lanm) is an FDA-approved neuromodulator used to smooth frown lines (like the “11s” between the brows). Like Botox, it temporarily relaxes the tiny facial muscles that create dynamic wrinkles—so skin looks softer and more relaxed.
Daxxify can provide wrinkle-smoothing effects for up to six months. This makes it an attractive option for those seeking fewer touch-ups. Large clinical studies (SAKURA program) found a median response of ~24 weeks (≈6 months) with many patients maintaining none or mild frown lines through Week 24. PubMed+1
Quick facts
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Onset: early changes in a few days; full effect ~7–14 days
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Typical duration: ~6 months for many patients (some longer)
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On-label area: glabellar (frown) lines
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Common off-label (provider-dependent): forehead lines, crow’s feet, brow lift, lip lines, masseter slimming, platysmal bands
How Does Daxxify work?
Daxxify works by inhibiting muscle contraction through a peptide chain that prevents the release of acetylcholine at the neuromuscular junction. The longer-lasting effects are due to the unique peptide formulation, which helps the solution remain active in the muscles for longer.
Like other botulinum toxin type A products, Daxxify temporarily blocks acetylcholine release at the neuromuscular junction, relaxing targeted facial muscles so dynamic lines soften. The peptide excipient reduces surface adsorption and enhances thermal stability of the formulation, supporting reliable performance in practice. Results begin within a few days and mature by ~1–2 weeks in most patients. FDA Access Data
What Is Botox?
Botox, the market leader in wrinkle treatment, also works by relaxing facial muscles. Botox Cosmetic (onabotulinumtoxinA) is the most widely known neuromodulator for aesthetic lines of expression, FDA-approved for glabellar lines, forehead lines, and lateral canthal (crow’s feet) lines. It has decades of real-world use and safety data. FDA Access Data.
How Does Botox Work?
It uses botulinum toxin to block the nerve signals that cause muscle contraction, thus smoothing out wrinkles and fine lines. Botox uses the same core mechanism as Daxxify to reduce targeted muscle activity and soften expression lines. Initial effect typically appears in 1–3 days, builds over the first week, and the duration for glabellar lines averages ~3–4 months. FDA Access Data+1
Botox is FDA-approved and has been used in aesthetic medicine for years, with proven results. However, it typically requires re-treatment every three to four months.
Daxxify vs Botox Comparison
| Factor | Daxxify | Botox |
|---|---|---|
| Effectiveness | Lasts up to 6 months, providing longer-lasting results. | Lasts 3 to 4 months, requiring more frequent touch-ups. |
| Side Effects | Similar to Botox; mild bruising, headache, and swelling. | Bruising, headaches, and mild swelling. |
| Cost | More expensive per unit, but fewer touch-ups needed over time. | Less expensive per unit, but more frequent treatments can increase long-term costs. |
How Long Do Results Last with Daxxify?
Daxxify’s primary appeal is its longevity, with results lasting up to six months. In comparison, Botox typically lasts between three and four months before touch-ups are needed. For those who want fewer appointments, Daxxify’s extended duration may be more appealing.
What determines the longevity of Botox and Daxxify? Dose, muscle strength, treatment area, individual metabolism, and how precisely injections match your movement patterns. Many patients who metabolize toxins quickly prefer Daxxify for fewer yearly visits; those who like more frequent, finer dose adjustments may prefer Botox. PMC
Cost Comparison: Daxxify vs Botox
Cost plays a significant role in choosing between Daxxify and Botox. While Botox is less expensive per unit, patients may need more frequent treatments, leading to higher long-term costs.
Daxxify, with its extended duration, may initially cost more but could offer better value over time for those who prefer fewer visits.
Side Effects and Risks of Daxxify and Botox
Both Daxxify and Botox carry similar side effects, including:
- Bruising at the injection site:
It occurs when small blood vessels are disrupted during the injection, leading to temporary discoloration.
- Headaches:
Some patients may experience headaches as a mild reaction after the injection, which usually subsides within a few hours.
- Muscle weakness:
The injected botulinum toxin can sometimes spread to surrounding muscles, leading to temporary weakness in the treated area.
- Allergic reactions (rare):
Though uncommon, some individuals may experience allergic reactions such as rash, itching, or swelling, typically due to the body’s sensitivity to the ingredients.
It is suggested to always consult with a licensed professional to minimize risks.
How to Prepare for Your Daxxify or Botox Treatment?
Preparing for Daxxify treatment is straightforward. Here’s what to expect:
- Consultation:
Discuss your skin type, wrinkle severity, and treatment goals with a licensed practitioner.
- Pre-treatment Guidelines:
Avoid alcohol and blood thinners before treatment to reduce the risk of bruising.
- Injection Process:
The procedure involves minimal discomfort, with most patients describing it as quick and tolerable.
- Recovery and Aftercare
After your Daxxify or Botox treatment, you can expect minimal downtime. Mild swelling or redness may occur, but these side effects usually subside within a few hours to a day.
1–2 weeks before
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Tell your injector about recent procedures, dental work, illnesses, or active skin issues in treatment areas.
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If your clinician approves, consider pausing blood-thinning supplements (fish oil, high-dose vitamin E, ginkgo, garlic) to reduce bruising risk.
24–48 hours before
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Minimize alcohol.
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Arrive with clean skin or be ready for a gentle cleanse.
Day of treatment
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Review medical history, medications, allergies, and prior responses to toxins.
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Align on aesthetic goals (natural movement vs. maximal smoothing; brow position; smile dynamics).
Aftercare (first 24 hours)
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Stay upright ~3–4 hours.
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Avoid rubbing/massaging injection sites the day of treatment.
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Skip hot yoga/sauna and very strenuous exercise until the next day.
These steps help limit unintended diffusion and bruising. Cleveland Clinic+1
Conclusion
Both Daxxify and Botox are effective treatments for reducing wrinkles and fine lines, with each offering different benefits depending on your personal goals and preferences. Most people go with daxxify because of its longer-lasting results, providing up to six months of smooth skin, which can be ideal for those seeking fewer touch-ups and a more convenient, long-term solution. Always consult with a licensed professional to make the most informed decision.
Frequently Asked Questions
Q. Daxxify and Botox: Which Treatment Is Right for Me?
The right choice between Daxxify and Botox depends on several factors, including your aesthetic goals, budget, and tolerance for maintenance. It is always better to consult with a professional before making a decision.
Q. How long do Daxxify and Botox results last?
Daxxify lasts up to 6 months, while Botox typically lasts between 3 to 4 months.
Q. Is Daxxify better than Botox?
Daxxify offers longer-lasting results, which is why most people prefer Daxxify for long-term use.
Q. Are there any side effects of Daxxify and Botox?
Both treatments can cause bruising, headaches, and swelling. Allergic reactions are rare but possible. Also, these risks tend to occur for a short period of time.
Q. Which is more affordable, Daxxify or Botox?
Botox is generally less expensive per unit, but Daxxify’s longer-lasting results can provide better value in the long run.
Q. Can I get Daxxify if I’ve used Botox before?
Yes, many patients transition from Botox to Daxxify for longer-lasting results.
Q. How do I prepare for Daxxify or Botox?
Avoid alcohol and blood thinners prior to your treatment. A consultation with your provider is essential for tailored advice.
Q. Is Daxxify “stronger” than Botox?
They’re different formulations of botulinum toxin A; units are not interchangeable. In trials, Daxxify’s effect in frown lines typically lasts longer (median ~24 weeks) than Botox’s ~3–4 months, but individual results vary by area and dose. PubMed+2PMC+2
Q. What’s unique about Daxxify’s formula?
A peptide stabilizer (RTP004)—no human or animal-derived albumin—improves stability and handling. FDA Access Data
Q. How soon will I see results?
Both start working within a few days, with full effect by ~1–2 weeks. FDA Access Data
Q. Can I switch between products or mix areas?
Yes. Many of our patients use Daxxify for longevity in the glabella and Botox in other areas based on preference and response. Your injector will guide area-specific dosing.
Q. How often should I schedule maintenance?
Plan ~every 6 months for Daxxify (some sooner/later) and every 3–4 months for Botox to keep lines from re-etching. Some patients prefer to use Daxxify every 3-4 months to maximize the benefits of appearance prior to any reduction in the perfomance of the injectable. PubMed+2PMC+2
Q. What are the common side effects?
Temporary redness, swelling, or bruising at injection points; occasional headache; less commonly, transient eyelid or brow heaviness. Discuss full risks/contraindications during consent. (See FDA labels.) FDA Access Data+1
Need Daxxify or Botox Services in Denver? Book Your Consultation Now!
If you’re interested in exploring Daxxify treatment or Botox treatment for wrinkles, book your consultation now at Cunningham Clinic. Our professionals will help you decide which injectable is right for your needs and guide you through every step of the process.
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