DAXXIFY – the long-lasting wrinkle treatment

Many in Denver have asked us about the newest injectable to hit the market – Daxxify. The excitement is really due to studies that show that Daxxify lasts on average 6 months and up to 9 months for some.  If you’re like most people, you probably get a frown line treatment around twice a year. But here’s the thing: conventional treatments only last 3–4 months. That means you may spend the next 2-3 months of the year with those frown lines staring back at you between treatments. That’s up to 4-6 months of total wear off time per year! Daxxify is different. With those same 2 treatment visits, you can keep your frown lines smoother for a full year!



Daxxify, also known as daxibotulinumtoxina-lanm or Daxi, was created by the Nashville-based company Revance Therapeutics Inc, and is a part of a family of neuromodulators that use injections of a small amount of botulinum toxin to smooth wrinkles for a more youthful appearance. In the same way that Botox and Dysport are used to treat dynamic wrinkles, Daxxify is used to treat wrinkles that form as a result of repeated muscle movements.  FDA approval has been granted for Daxxify for treating glabellar lines, also known as frown lines, which appear as vertical lines between the eyebrows.  Daxxify reduces the appearance of severe frown lines by relaxing the muscles that cause them.  The long- lasting nature of Daxxify distinguishes it from Botox and other neuromodulators.


Why we believe we are the best choice for Daxxify in Denver and Cherry Creek

As a leading provider of new cosmetic treatments, Cunningham Clinic is excited to offer a proven, safe and effective new anti-wrinkle injection option with Daxxify at our clinic in Denver.  Having extensive experience with cosmetic treatments, Cunningham Clinic is always one of the first health care professionals to adopt newly FDA-approved treatments, providing patients with the best treatments on the market.

Cunningham Clinic is highly experienced and a leader in anti-aging treatments, including injectable neuromodulators, such as Botox, Juvederm, and Sculptra, and a wide variety of other cosmetic and medical treatments. Well known for expert care and high patient satisfaction, Cunningham Clinic has been rated one of Denver’s best health care providers.

Frequently asked questions

Using Daxxify, you can smooth dynamic wrinkles. Dynamic wrinkles form as a result of repeated muscle contraction in a given area. When you smile, you can create smile lines around your mouth and crow’s feet around your eye, while when you frown or furrow the brow, you can create horizontal forehead lines or frown lines between your eyebrows as a result of your facial expressions. During our youth, dynamic wrinkles only appear when we make certain facial expressions, then smooth out when the face is at rest. When we age, dynamic wrinkles are etched into our skin, creating wrinkles even when our faces are still. Aesthetic treatments like Botox and Daxxify, can reverse these tell-tale signs of aging.

The Daxxify procedure involves the injection of the neuromodulator daxibotulinumtoxina-lanm into the muscles responsible for dynamic wrinkles, working to block the nerve signal that tells the muscle to contract. The muscle can then relax, smoothing out wrinkles in the area and preventing new wrinkles from forming. This anti-wrinkle temporary improvement of the Daxxify treatment can be observed for up to six months, making it the longest lasting injectable neuromodulator available on the aesthetic market.

Daxxify was approved by the U.S. Food and Drug Administration (FDA) on September 8th, 2022  Daxxify was studied in the largest-ever clinical study for a frown line treatment and included more than 2,800 people across different ages and skin types. Here are some things you should know about DAXXIFY®:

There were no serious treatment-related side effects

The active ingredient in DAXXIFY® is botulinum toxin type A, an ingredient that has been used in frown line treatments for more than 20 years

96% of people treated with DAXXIFY® were satisfied with their results

Daxxify is the only long-lasting frown line treatment stabilized by a peptide. Results last on average 6 months and up to 9 months for some. All frown line treatments require a special ingredient to stabilize botulinum toxin A, the protein responsible for helping smooth moderate to severe frown lines. For instance, BOTOX® Cosmetic uses human serum albumin (HSA), a blood product, as its stabilizer. Dysport®, another frown line treatment, uses HSA as a stabilizer and cow’s milk protein as a protectant.

DAXXIFY® is unique because it is the only formulation that uses a novel peptide as a stabilizer and does not contain human or animal byproducts.

In short, no, and here’s why. Units are like fingerprints—they are a proprietary measurement of a treatment’s unique potency. Because of the differences in how treatments are formulated and tested, you cannot compare or convert Units between them, just like you cannot compare 2 fingerprints.

A clearer way to understand dosing is to look at how many nanograms of active ingredient (botulinum toxin type A) a product has.

Double the Units does not mean double the dose


Approved frown line dose: 40 Units

Amount of active ingredient: 0.18 nanograms

BOTOX® Cosmetic

Approved frown line dose: 20 Units

Amount of active ingredient: 0.18 nanograms


Approved frown line dose: 50 Units

Amount of active ingredient: 0.27 nanograms

You may see results with DAXXIFY® as early as the next day after treatment, and typically within two days

Is your wrinkle treatment not lasting as long as you would like? If so, Daxxify could be the solution for you. Discuss your treatment goals with Cunningham Clinic. Click here to book a free aesthetic consultation now!